Charles was the only surviving son of his Habsburg predecessor, King Philip IV of Spain and his second Queen (and niece), Mariana of Austria, another Habsburg. His birth was greeted with joy by the Spaniards, who feared the disputed succession which could have ensued if Philip IV had left no male heir.
Pedigree of Charles II. Note large amount of inbreeding.
16th century European noble culture commonly matched cousin-to-first-cousin and uncle-to-niece, to preserve a prosperous family's properties. Charles' own immediate pedigree was exceptionally populated with nieces giving birth to children of their uncles: Charles' mother was niece of Charles' father, being daughter of Maria Anna of Spain (1606–46) and Emperor Ferdinand III. Thus, Empress Maria Anna was simultaneously his aunt and grandmother.[1] This inbreeding had given many in the family hereditary weaknesses. That Habsburg generation was more prone to still-births than were peasants in Spanish villages.[2] There was also insanity in Charles' family; his great-great-great(-great-great, depending along which lineage one counts) grandmother, Joanna of Castile ("Joanna the Mad"), mother of the Spanish King Charles I (who was also Holy Roman Emperor Charles V) became completely insane early in life.
Since about 1550 AD, outbreeding in Charles II's lineage had ceased. From then on, all his ancestors were in one way or another descendants of Joanna the Mad and Philip I of Castile, and among these just the royal houses of Spain, Austria and Bavaria. Charles II's genome was more homozygous than in an average brother-sister offspring.[2] He was born physically and mentally disabled, and disfigured. Possibly through affliction with mandibular prognathism, he was unable to chew. His tongue was so large that his speech could barely be understood, and he frequently drooled. He may also have suffered from the endocrine disease acromegaly.[3]
Consequently, Charles II is known in Spanish history as El Hechizado ("The Hexed") from the popular belief – to which Charles himself subscribed – that his physical and mental disabilities were caused by "sorcery". The king was exorcised, and the case of his exorcisms remains of the most sinister of the history of Spain.
Having learned to speak at age of four and to walk at eight,[2] he was treated as virtually an infant in arms until he was ten years old. Fearing the frail child would be overtaxed, he was left entirely uneducated, and his indolence was indulged to such an extent that he was not even expected to be clean. When his half-brother Don John of Austria, a natural son of Philip IV, obtained power by exiling the queen mother from court, he covered his nose and insisted that the king should at least brush his hair.[3]
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