The idea is basically to accept missions (if any) to boost troops or money, secure whatever easy rebel provinces are mission-applicable, and take any economic powerhouses in range, prepare for the inevitable Venetian/Sicilian assault, secure border with Turkey, counterassault the Italians, secure peace with the Papal states, build defenses in northern Greece, prepare for the inevitable betrayal by Hungary, and begin the religious conversion of the east and west.

Priorities will be determined by in-game events. I will update this thread when I've made significant progress.