I entirely agree with Drone. Play for a short while on easy then switch over to normal or hard depending on how well you've adapted from 3D to 2D. Really, I believe it's the small things that will bug you the most - you're probably used to using the left-mouse button to select your troops, and the right-mouse button to move/attack - in MTW 90% of the time you'll only ever be using the left button, the RMB in MTW changes the camera view so expect to be frustrated.
I also recommend playing the tutorial if you haven't already, especially the campaign tutorial, as while the entire game is different to RTW and M2TW, the biggest change would have to be the campaign map. As for a faction to play as, I recommend (for the first run through at least) the Vikings on the VI campaign. You'll have nice, strong infantry to help you get around the learning curve.
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