1. Yes, but I actually prefer to play it in windowed mode. To make it windowed mode, add "-w" into the shortcut. The max resolution is 800x600 iirc which is quite low. Anyways, I do a ton of AT runs and running it in a window makes the loading time between runs much quicker. Also, -ns will remove all sound which is also nice in runs, but you can't switch between acts online with that on.
2. Yes, basically, you go into either the right or left click menu and place your cursor over the skill. Press any key from F1-F12 and that skill will be assigned the hotkey. I'm pretty sure you can map it to keys other than the F#s but I don't remember how to do it atm.
A good basic barb build is whirlwind. You basically get 20 WW, 20 Shout, 20 BO, and 20 in your chosen weapon mastery. The most optimal one, I think, is axe and you use 2 of them allowing to get nice off hand modifiers, but if you're just starting out, polearm or sword is probably better off. For swords, though, you need to invest in dex for weapon requirements which is pretty bad since you're not going to use a shield and ar can be easily taken care of with either angelics jewlery or enchant from demon limb.
Anyways...I suggest to just save the weapon mastery points until you have a good idea of what endgame weapon you want to use first
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