Yes and no for me.

I am perfectly fine with modern shooters, but can't seem to play older ones for long.

I reinstalled the original Half-Life a while ago and found that after I played for 15 minutes or so, I became extremely nauseous and had to lie down for a while. I think it has to do with poor graphics coupled with the use of monitors with high native resolutions.

A bigger problem with me is my current keyboard placement. ATM, my hand/wrist starts to hurt after I play a while which is not a good sign at all, but I'm sticking to using my computer in the basement since it is way too hot in my room.