I can recommend both the Balance of Power Mod (BOP) and/or the Ultimate Dominion Mod 3 (UDM3).
The former is often described as BOTF as it *should've* been, and I agree with that assessment -- it just feels much better balanced overall (hence the mod's name), and the major races now tend to play a bit more like they should. Of course, UDM3 alters the game even more dramatically since it replaces the Ferengi with the Dominion (although the Ferengi are still in the game as a minor race), and it radically redoes the shiplists for all 5 powers (including new ship graphics, which look incredible).
Either way, you can't really go wrong with either one.

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