With the component isolation and surface area, I would imagine heat wouldn't be a problem for peripherals. You might run into a few issues with routing the wiring (length mainly), but it looks pretty slick.

Not sure about the noise levels you would get, but if they are low enough, it would be nice if they put in some kind of bracket for an LCD to attach on the backside. Then you could put the whole thing on the desk, and move everything with the top handle.