In Alexandro's eyes, Italia was probably a bunch of Koine Barbaropolios that annoys the civilized people of Megas Hellas. Certainly one Barbaropolis ton Rhomaion would be no different from others of Italia, especially considering that the Etruscan, barbaroi too, were probably considered -almost- greek and thus a bigger power.

If Alexandros wanted to go west, Italia (and subsequently the barbaroi that inhabit it) would only be a first stage. I'm curious on what would alexandros do when he reaches the pillar of herakles though......