I voted disagree but "Gah!" might be better.

As with religion, it's actually the people who make it, not a supreme being.

I think God's existence is of consequence to human existence, especially if you give a about him/her/it. In terms of day to day impact, I should imagine many faithfull people consider their actions acording to what "he" has "said" he would like/advise them to do.

But I don't really think I feel the tremours of a supreme being's will.