Don't take excedrin or any other pain killer like tylenol or advil after a night of drinking because you will kill your liver You to wait at least 12 hours from the time you had your last drink, and that is still pushing it, I would wait a day. If you drink every day, then you are SOL. I know so many people who take pills before they go to bed after drinking, or wake up 3 hours in to take a pill, and the bottles clearly say that if you consume two or more drinks you should not take these pills.
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