Clinton lost because she's Clinton, Americans were never going to vote for the wife of a former President. That sort of political Dynasty was never going to fly in the US, especially with it having previously happened in South America.
Doubtful. Leaving aside that most presidents are distant relations of one another or of the Founding Fathers (e.g. the Roosevelts), we've had the Adams, the Harrisons, and the Bushes, but a husband and a wife is a dynasty too far?