I completed my Mass Effect playthrough at level 59, so I started another on hardcore. I ran through the story in ~7 hours; it was quite easy, with the exception of one or two spots. Master immunity combined with spectre X gear meant my character was a near-invincible tank of doom. It's far more fun on hardcore difficulty, as you need to use all of your abilities and squad powers frequently to survive. Taking cover is something other than a gimmic; I didn't think the game had so many ways to die in a single shot!

I'm intending to hunt down the remaining silver keys and gargoyles in Fable II. Once I'm done with that I'll head back to Mass Effect and try insanity. Three playthroughs completed and I still want to play it again; that's practically unique for me.