Castles (Interplay). Yeah, Stronghold kind of fills the same niche, but it just wasn't as good IMO.
Battle Isle series - Good old hex-based strategy gaming with futuristic units. Hex gaming is a dying genre, unless you want to play WW2 battles endlessly.
Monkey Island - We need more comedy games!
Dungeon Keeper - Being evil is fun. This name brand might be dead, but I suspect we'll see the idea reappear at some point though.
Bookmarks