Well, I just got done with bringing down the sky and it was pretty fun. This is my second playthrough, I'm on hardcore with a level 50 something vanguard. Those missle towers make quick work of the Mako, I had to save every two towers I took down unless I wanted to go through the gauntlet over and over.
The funny thing, my first time with the game I got almost all paragon, this second time I'm trying to go renegade, yet somehow I still mange to have a higher level of paragon, maybe I'm still being too nice. It's fun to see Sheperd go bad ass on people.
I agree with Kekvit, your going to need those special powers once you step up the difficulty, great armor and guns help alot, but sometimes you'll need that extra push to take down aliens. Liara is awesome with biotics of course, she was a major asset when I took on Benezia the first time around. Most of the time I use Tali and Ashley together, or Garrus or Ashley, or Liara and any of those menttioned, I probablly don't use Wrex and that other guy that offten, especially that other guy, I can't even remember his name I barely use him ha ha ha.
I haven't made it too far into hardcore yet, only did a few side missions and rescued Liara, so maybe my teams will have to get switched up again depending on what kind of stiff resistance the AI will put.
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