I went VH/M for my first (and only!) EB campaign. I've taken over the entire east except for Sauromatae territory but I had started a few campaigns before where, as Seleukia, I got absolutely stomped by Pahlava, Pontus and the Saka. I guess that's why I decided to attack the east and just keeping Damaskus fortified against the Ptolemies, but at this point I have so much cash I can literally raise an army of elephants and just stomp anything in my way. I tried taking on the Ptolemies in the campaign before and I got chewed up and spat out, and then I lost the entire east to Pahlava. I'm the sort of obsessive person who hates losing ANY provinces.