The civil war will happen for all factions under human control.
In regards to the Seleucid campaign, I find it beneficial to sell peace to that Quidry one-province state south of my starting position for 5000 gold, and selling some trade agreements (however you can get about 3-4 trade agreements before the AIs start refusing you due to lack of resources on your end, so choose wisely). You can sell a trade agreement for as high as 2500 I think, and several for 1000-1500.
Also, the initial stack in Antioch (the one with the merc elephants) can crush Cyprus on its own. Leading battles with the Seleucids early on is a must IMO.
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