If UK affiliate Pharma companies get in enough trouble, there is a track record of the entire senior management team getting sacked and replaced. Not parachuted out. Not paid off. But booted en masse. That sort of thing helps ensure senior interest on doing the right thing if only to keep their own career. If you keep breaking the rules, the PMCPA passes you over to the MHRA and there the pain really starts. They can send people to jail for jeopardizing patient safety, and even take away the Market Authority of a drug, or force companies to supply it to everyone for free. And the agencies talk - if the MHRA is not happy expect the EMA and especially the FDA to also take an interest enter the billion dollar fines.
I think that in the USA things are significantly different since there is no NHS and power is a lot more with Doctors. In the UK a company could be frozen out of the entire market for one or all of their drugs in essence for ever if that was decided. In the USA I don't think that this is possible - and there is so much more money in the system and more ways of bribing the players that they probably do in more cases accept the risk.
I don't for one minute think that those in the Industry are more honest or "nice" they just know that problems are generally quickly detected, and that fines are in essence infinite.
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