It didn't get inflexible and the Makedonian Syntagma didn't change. Were did you hear/read something like that? Please get your facts right dude. The only thing that probably happened, is that the pikes were further lengthened about a meter. The formation remained the same: 256 (16x16) man blocks typically, with 5 rows in front having their pikes lowered parallel to the ground and the rest in an angle that rose the further back you went.
The only thing that changed, is that more and more pikemen were used and less and less cavalry. Alexandros used approsimately 9,000 Pezhetairoi IIRC, while later Basileis like Perseus fielded from 16,000 to even 22,000 I believe.
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