My best guess is that they see using a drug as an immoral act.
There are generally 5 spheres of morality, 5 different types of things we find immoral (harm, fairness, authority, community, and purity, at least that's what he calls them
here).
An example of the purity sphere could be found in this paragraph:
Our bodies are meant to be chaste and modest temples of the Holy Spirit so that we can relate to others through our hearts with true love. Our bodies are not meant to be covered with the graffiti of tattoos (Leviticus 19:28), or made into works of “art” with fashionable costumes, piercings, hair dye, gaudy make up, shaven heads, or hostile punk hair styles. Our bodies are not meant to be defiled by making our reproductive organs into the equipment of a recreational sport. Nor are our bodies meant to be made into instruments of social acceptance, expressions of vanity and pride, or provocations to lust.
Now, drug use goes against the purity morality (along with things like tattoos, piercings, homosexuality). It also goes against authority because it is illegal. And against community because drugs are seen as something that "tears apart communities" or "would lead to a general laziness in society" (I think Xiahou said that once).
According to polling, conservatives rate community, purity, and authority as much more important that liberals do. Harm and fairness take priority for liberals. So it's no surprise that drug legalization is more favored by liberals.
So, just as radical islamists are outraged by things like this:
Last month a British woman teaching in a private school in Sudan allowed her class to name a teddy bear after the most popular boy in the class, who bore the name of the founder of Islam. She was jailed for blasphemy and threatened with a public flogging, while a mob outside the prison demanded her death. To the protesters, the woman’s life clearly had less value than maximizing the dignity of their religion
Because they overvalue certain moral spheres, many conservatives take a ridiculous stance on drug laws because they overvalue certain moral spheres.
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