I started a campaign with Spain, gave myself enough cash to survive (surprisingly, I took on 750000 florins, and it took me until 1728-29 until I made a decent profit!!!). This one is on VH/VH, and it is more challenging, but if you manage to fend off the first 50 turns or so, then you can basically relax since the AI won't attack you any more.

However Maratha Confederacy is starting to be a bit of a concern, since they almost conquered the whole of the Ottoman Empire and the whole of India as well.

But Spain is enjoyable. Conquered Portugal, Morocco and now New Spain is under my umbrella.

I'm somewhat surprised - New Spain only gives me around 3k per turn. The whole area.