The Sims franchise definitely tops Guitar Hero, but it is spread out over many expansion packs, while the profits of Guitar Hero 3 is just a single game.
Also of note is World of Warcraft. Even though a few months worth of fees (10 million users) completely destroys GH3's profits, the sales of actual units are quite dismal as most can download the client for free or buy it for around five dollars on CD.
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