I second the expansion into Kyushu after Shikoku, though I would think that would be common knowledge. Kyushu is the money-making capitol of Japan in Shogun 2. I would even go as far as to say that any clan you play in the game should make an attempt for Kyushu - even the Date who are the furthest away from it. The possibilities of cash flow that come from it (being primarly coastal cities with ports) and the, rather unbalanced, collection of trade resource nodes nearby should make it a prime target for any clan. I will always try and make it a priority in my games, and if I don't, I regret that I didn't later in the game.
Aside from being a cash cow, it's an extremely defensible position once the whole of it has been taken, what with only one land route in the north east... though the AI is definitely more prone to water invasions in this game than previous titles. Still, the money you make from it is more than enough to pay for the fleets required to defend it and then some.
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