I have never played Uesugi on Legendary. I used to read people recommending to defeat Ikko-Ikki first, but the religious unrest will tie us up while we don't have enough good monks to shorten the pain.
Here are two ideas:
The New Hojo: As soon as the game starts, beat Jimbo and force a treaty. Then sell military accesses to all our friendly neighbors, gather a good 1/2-2/3 stack of Ashigaru, and rush south to eliminate Hojo. It should be quite easy to do as it is still early game. After Hojo is done, work on Imagawa and Takeda, but maybe consider forcing a treaty with them - since we want to focus on expanding all the way to Iwate and Higo.
The New Shoni: Sell military accesses and use that money to keep hiring Bow Kobaya from Echigo, and sail every ship west as soon as it comes out, but only use 95% of the movement points for later relay purpose. Once a full stack of Ashigaru is achieved, board the ship with everything you have (a Monk + a Ninja is highly recommended) and use the navy relay method to quickly ship every thing you have all the way west to Hizen. Purposely lose Echigo to rebels (raise the tax the turn before you take Hizen) so you can get trade routes better setup later.
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