Probably not, I'd say. After the end of the CKII timeframe is when their new game, EUIV, begins. However, it is speculated that with the release of EUIV there will be a DLC that you can use to convert your finished CKII game into an EUIV game and start from there.
As for the next big expansion DLC... I am predicting playable Holy Orders. Or perhaps bishops/theocracies in general. But I find it more likely that they'd come up with a mechanic for a player to control a Holy Order as a tool of the crusades, perhaps giving up land to secular rulers of their religion after they have won it from the infidels. It would certainly bring the emphasis of Crusader Kings back onto the Crusades, anyway.
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