Pissing off Makedonia shouldn't be too much of a problem. As soon as you take Mytilene, they will be forced to walk along the northern shores of the Aegean Sea to get to you, and they will probably head for either Tylis or Byzantion first. The problem for them, though, is that there's a bridge just after they have crossed into your territory, a bridge they will have to cross if they want to reach any of your cities. If they capture Serdike however, they will have the opportunity to go through the mountain-pass there, making defending your territory alittle more difficult.
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