True, a shallow breeding pool just tends to bring recessive genes to the front. And often these tend to be mutations and some stuff. So loads (read LOADS) of inbreeding can get rid of the correct genes and just leave you with mutations.
AND, it would show up as soon as it happened, not magically appear 450 years down the track.
So everyone, it is safe to sleep with your sister. Just really disgusting morally and illegal in all western countries. Except 1st cousins are allowed to marry in Japan. Apparently thats far enough apart on the family tree.
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